Enzymes in the steroidogenic pathway

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Enzymes in the steroidogenic pathway.

Hydroxysteroid sulfotransferase [HST]

Pathway:

Dehydroepiandrosterone à Dehydroepiandrosterone Sulfate

Dehydroepiandrosterone ß Dehydroepiandrosterone Sulfate

Reaction: 3b-hydroxysteroid sulfotransferase

Cofactors: Glutathione [1]; Fe2+ [1]; Co2+ [1]; Mn2+ [1];

Inhibitors: 2-Mercaptoethanol [2]; HgCl2 [1] (mercury compounds)

Enzyme Synonyms: Hydroxysteroid sulfotransferase; Alcohol sulfotransferase; Sulfotransferase,

3beta-hydroxy steroid; DELTA5-3beta-Hydroxysteroid sulfokinase; 3b -Hydroxy steroid sulfotransferase;

3-Hydroxysteroid sulfotransferase; HST; 5alpha-Androstenol sulfotransferase; Cholesterol

sulfotransferase; Dehydroepiandrosterone sulfotransferase; Estrogen sulfokinase; Estrogen

sulfotransferase; Steroid alcohol sulfotransferase; Steroid sulfokinase; Steroid sulfotransferase; Sterol

sulfokinase; Sterol sulfotransferase; Alcohol/hydroxysteroid sulfotransferase; 3beta-Hydroxysteroid

sulfotransferase

[1] Ryan, R.A., Carroll, J.: Biochim. Biophys. Acta, 429, 391-401 (1976)

[2] Lyon, E.S., Jakoby, W.B.: Arch. Biochem. Biophys., 202, 474-481 (1980)