Enzymes in the steroidogenic pathway

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Enzymes in the steroidogenic pathway.

17 b-hydroxysteroid dehydrogenase [17b-HSD]

Pathway:

Dehydroepiandrosterone à Androstenediol

Androstenedione à Testosterone

Estrone à Estradiol

Reaction: Redox reaction

Cofactors: Zinc [4]

Inhibitors: Ethanol [1], Licorice [2], phytoestrogens (flavonoids, coumarins, coumestans) , zearalenone, coumestrol, genistein, quercetin and biochanin A [3, 6], excessive copper [5]

Enzyme Synonyms: Dehydrogenase, beta-hydroxy steroid; 17beta-HSD; 17-Ketoreductase;

17beta-Hydroxy steroid dehydrogenase; 3beta-Hydroxysteroid dehydrogenase;

Dehydrogenase,17beta-hydroxy steroid

[1] Heyns, W., de Moor, P.: Biochim. Biophys. Acta, 358, 1-13 (1974)

[2] Sakamoto K, Wakabayashi K. Inhibitory effect of glycyrrhetinic acid on testosterone production in rat gonads.Endocrinol Jpn. 1988 Apr;35(2):333-42. [PubMed]

[3] Krazeisen A, Breitling R, Moller G, Adamski J. Phytoestrogens inhibit human 17beta-hydroxysteroid dehydrogenase type 5. Mol Cell Endocrinol. 2001 Jan 22;171(1-2):151-62. [PubMed]

[4] Arreola F, Paniagua R, Herrera J, Diaz-Bensussen S, Mondragon L, Bermudez JA, Perez Pasten E, Villalpando S. Low plasma zinc and androgen in insulin-dependent diabetes mellitus.
Arch Androl. 1986;16(2):151-4. [PubMed]

[5] Chattopadhyay A, Sarkar M, Sengupta R, Roychowdhury G, Biswas NM. Antitesticular effect of copper chloride in albino rats. J Toxicol Sci. 1999 Dec;24(5):393-7. [PubMed]

[6] Makela S, Poutanen M, Lehtimaki J, Kostian ML, Santti R, Vihko R. Estrogen-specific 17 beta-hydroxysteroid oxidoreductase type 1 (E.C. 1.1.1.62) as a possible target for the action of phytoestrogens. Proc Soc Exp Biol Med. 1995 Jan;208(1):51-9. [PubMed]