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Thyro-Mend™ |
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A synergistic combination of
iodine containing seaweeds, and herbs which contain phytothyroidogenic,
phyto-thyroid-receptor agonists, and other herbs designed to promote optimal
function of thyroid hormones by maintaining the health of thyroid hormone
producing tissues and by supporting the healthy function of tissues that
respond to thyroid hormones. |
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This unique combination of seaweeds
and herbs synergistically supports the SEVEN
KEY FUNCTIONS associated with OPTIMAL
THYROID HEALTH, due to its ability to support: |
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1. increased bio-available iodine for thyrocytes |
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2.
increased
iodine uptake by thyrocytes through interactions
with sodium-iodide-symporter ( |
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3.
increased T3
& T4 production and secretion from thyrocytes |
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4.
increased
conversion of thyroxine (T4) to the more bioactive triiodothyronine (T3) by liver
cells; |
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5.
increased
RXR/TR heterodimerization of thyroid receptors on target cells throughout the
body |
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6.
increased
binding of thyroid hormone receptors to DNA by RXR/TR heterodimers throughout
the body |
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7.
increased affect of T3 on target gene expression within
receptor cells throughout the body. |
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Please Find a Healthcare Professional in your area to purchase this formulation. |
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Three Capsules Contain: |
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Iodine
(from seaweed blend) |
200mg |
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Thyro-Mend™
Proprietary Blend |
1,700mg |
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Standardized Guggulipid (gum
resin, 2.5% guggul sterones),
Standardized Bacopa (aerial parts, 20% bacosides),
Standardized Hops (aerial parts, 5% alpha bitter acid), Sage (leaf),
Standardized Ashwagandha (root, 1.5% withanolides & 1% alkaloids), Standardized Coleus
(root, 10% forskolin), Standardized Rosemary
extract (aerial parts, 6% carnosic acid) &
seaweed blend (Fucus vesiculosus
& Ascophyllum nodosum) |
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Suggested
Use: |
3 daily with food |
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Also See: |
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MORE INFORMATION on the Constituents of Thyro-Mend™ |
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Sea Kelp (Ascophyllum nodosum) is a dietary source of bio-available iodine. An additional benefit of Ascophyllum nodosum is
its ability to increase glutathione peroxidase
activity, an important antioxidant. Human thyrocytes
synthesize and secrete extracellular glutathione peroxidase, which translocates
into the intracellular space and prevents peroxidative
damage of thyrocytes from diffusion of extracellular H202 during stimulation of thyroid-hormone
synthesis. |
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Bladderwrack (Fucus vesiculosus), another dietary source of
natural bio-available iodine, has been used by many societies
throughout history. Bladderwrack has also
demonstrated anti-estrogen properties in both human and animal studies,
suggesting that it may contribute protective health to estrogen sensitive
tissues. |
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Guggulsterone (Commiphora
mukul) has shown an ability to support thyroid
function, especially through increased conversion of T4 to T3 in the liver,
the principle site of T3 generation.* The effects of guggulsterone
may be due to its ability to activate multiple receptors on the nuclear
membrane, including thyroid receptors (alpha & beta), retinoic acid
receptors, (which pairs with thyroid receptors), and the vitamin D receptor,
which also plays a role in thyroid function. Guggulsterone,
a component of Commiphora mukul
supports healthy cholesterol
levels and affects LDL oxidation, an important feature since the
oxidation of LDL may have an effect on cardiovascular health, a critical
concern for those with sub-optimal thyroid function |
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Rosemary (Rosmarinus officinalis)
provides carnosic acid, a polyphenolic
diterpene that at low concentrations increases the
expression of vitamin D and retinoid receptors. Retinoid-X-receptors (RXR)
undergo heterodimerization with thyroid hormone receptors (TR). The RXR/TR
heterodimers have been proposed to be the principle mediators of target gene
regulation by T3 hormone. The ability of carnosic
acid to also affect retinoic acid receptors may increase its importance as a
TR agonist. Rosemary also contributes rosmarinic
acid, which has significant antioxidant and anxiolytic
properties. An additional constituent, carnosol,
may support healthy metalloproteinase-9 activity and healthy NF-kappaB activity, which may be responsible for its
support of normal immune system function. |
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Sage (Salvia
officinalis) has long been recognized as a very
rich source of the antioxidant carnosic acid which,
as noted above, can increase T3 activity through improved RXR/TR heterodimerization.
Important features of Salvia officinalis are
also its memory supportive properties, including memory retention, more
efficient memory retrieval and improved mood and cognitive task performance. |
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Ashwagandha (Withania somnifera)
demonstrated an ability to directly act on the thyroid to raise serum levels
of thyroid hormones in animal studies during the late 1990s. Though
inconclusive, a case review in late 2005 indicated that Ashwagandha
may have the ability to raise serum levels of thyroid hormones in humans. Ashwagandha has also been attributed as having a number
of adaptogenic properties including neuroprotective
properties. |
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Coleus (Coleus forskohlii)
contains forskolin, a potent activator of the
cyclic AMP-generating system in many tissues including the thyroid, and
increases T3 & T4 secretion from thyrocytes in
a fashion similar to TSH, though independent from TSH. Forskolin
is specifically able to mimic the effect of TSH in regard to iodide uptake, organification of iodine, thyroglobulin
(TG) production, and promote secretion of T3 & T4, through an increase in
the expression of sodium/iodide symporter ( |
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Brahmi (Bacopa monniera)
exhibited thyroid supportive properties through an increase of T4 serum concentrations
in animal studies. Brahmi may have more direct
thyroid supportive properties versus an effect on hepatic conversion to T3. Brahmi may also address concerns about neurocognitive
function associated with sub-optimal thyroid function. In human studies, Brahmi has been shown to improve many of the higher order
cognitive processes, including the ability to significantly improve speed of
visual information processing, learning rate, memory consolidation, improve
memory retention, enhance retention of new information, and decrease the rate
of forgetting of newly acquired information. |
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Hops (Humulus
lupulus) can increase the uptake of iodide into
the thyroid gland, a fundamental step in thyroid hormone synthesis, through interactions
with sodium-iodide-symporter ( |
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References: |
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Iodine: |
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Bladderwrack (Fucus vesiculosus): Campbell WR. Diet and
nutrition: iodine in normal nutrition. Can Med Assoc J. 1939 Jan; 40(1): 77-79. ● Butler MR. Comparison of the chemical composition of
some marine algae. Plant Physiol. 1931 Apr; 6(2): 295-305. ● Skibola CF. The effect of Fucus
vesiculosus, an edible
brown seaweed, upon menstrual cycle length and hormonal status in three
pre-menopausal women: a case report. BMC Complement Altern
Med. 2004 Aug 4;4:10. ● Skibola
CF, Curry JD, VandeVoort C, Conley A, Smith MT.
Brown kelp modulates endocrine hormones in female sprague-dawley
rats and in human luteinized granulosa
cells. J Nutr. 2005 Feb;135(2):296-300.
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Norwegian Seaweed (Ascophyllum nodosum): Butler MR. Comparison of the chemical composition of some marine algae. Plant Physiol. 1931
Apr; 6(2): 295-305. ● Howie AF, Walker SW, Akesson B, Arthur JR, Beckett GJ. Thyroidal extracellular glutathione peroxidase:
a potential regulator of thyroid-hormone synthesis. Biochem
J. 1995 Jun 15;308 ( Pt 3):713-7. ● Saker KE, Fike JH, Veit H, Ward DL. Brown seaweed- (Tasco)
treated conserved forage enhances antioxidant status and immune function in
heat-stressed wether lambs. J Anim
Physiol Anim Nutr (Berl). 2004 Apr;88(3-4):122-30. |
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Guggulsterones (Commiphora mukul): Panda S, Kar A. Gugulu (Commiphora mukul) induces triiodothyronine production: possible
involvement of lipid peroxidation. Life Sci. 1999;65(12):PL137-41. ● Panda S, Kar
A. Guggulu (Commiphora mukul) potentially ameliorates hypothyroidism in female
mice. Phytother Res. 2005 Jan;19(1):78-80.
● |
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Rosemary (Rosmarinus
officinalis): Steiner M, Priel
I, Giat J, Levy J, Sharoni
Y, Danilenko M. Carnosic
acid inhibits proliferation and augments differentiation of human leukemic cells induced by 1,25-dihydroxyvitamin D3 and retinoic
acid. Nutr Cancer. 2001;41(1-2):135-44.
● Danilenko M, Wang X, Studzinski
GP. Carnosic acid and promotion of monocytic differentiation of HL60-G cells initiated by
other agents. J Natl Cancer Inst. 2001 Aug 15;93(16):1224-33. ● Li D, Li T, Wang F, Tian H, Samuels HH.Functional
evidence for retinoid X receptor (RXR) as a nonsilent
partner in the thyroid hormone receptor/RXR heterodimer.
Mol Cell Biol. 2002 Aug;22(16):5782-92. ● Lee
S, Privalsky ML. Heterodimers of retinoic acid
receptors and thyroid hormone receptors display unique combinatorial
regulatory properties. Mol Endocrinol. 2005 Apr;19(4):863-78. ● Petersen M, Simmonds
MS. Rosmarinic acid. Phytochemistry.
2003 Jan;62(2):121-5. Review. ● Pereira P, Tysca D, Oliveira P, da Silva Brum LF, Picada JN, Ardenghi P. Neurobehavioral and genotoxic
aspects of rosmarinic acid. Pharmacol
Res. 2005 Sep;52(3):199-203 ● |
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Sage (Salvia officinalis): Rutherford DM, Nielsen MP, |
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Ashwagandha (Withania somnifera): Panda S, Kar A.
Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol. 1998 Sep;50(9):1065-8. ● Panda S, Kar A. Withania somnifera and Bauhinia purpurea
in the regulation of circulating thyroid hormone concentrations in female
mice. J Ethnopharmacol. 1999 Nov 1;67(2):233-9. ● van der Hooft CS, Hoekstra A,
Winter A, de Smet PA, Stricker
BH. [Thyrotoxicosis following the use of ashwagandha] Ned Tijdschr Geneeskd. 2005 Nov 19;149(47):2637-8.
Dutch. ● Ahmad M, Saleem
S, Ahmad AS, Ansari MA, Yousuf
S, |
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Coleus (Coleus forskohlii): Laurberg
P. Forskolin stimulation of thyroid secretion of T4
and T3. FEBS Lett. 1984 May 21;170(2):273-6.
● Hiraiwa M. Adenylate
cyclase system responsive to thyroid stimulating
hormone (TSH) of porcine thyroid cells in primary monolayer cultures.
Potential effect of forskolin on TSH-mediated adenylate cyclase stimulation. |
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Brahmi (Bacopa monniera): Kar A,
Panda S, Bharti S. Relative efficacy of three
medicinal plant extracts in the alteration of thyroid hormone concentrations
in male mice. J Ethnopharmacol. 2002 Jul;81(2):281-5. ● Jyoti A,
Sharma D. Neuroprotective role of Bacopa monniera extract against aluminium-induced
oxidative stress in the hippocampus of rat brain. Neurotoxicology.
2006 Feb 22 ● Roodenrys S, Booth D, Bulzomi S, Phipps A, Micallef
C, Smoker J. Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology.
2002 Aug;27(2):279-81. ● Sairam
K, Dorababu M, Goel RK,
Bhattacharya SK. Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats. Phytomedicine. 2002 Apr;9(3):207-11.
● Stough C, Lloyd J, Clarke J, |
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Hops (Humulus lupulus): Radovic B, Schmutzler C, Kohrle J. Xanthohumol
stimulates iodide uptake in rat thyroid-derived FRTL-5 cells. Mol Nutr Food Res. 2005 Sep;49(9):832-6.
● Casaschi A, Maiyoh GK, Rubio
BK, Li RW, Adeli K, Theriault
AG. The chalcone xanthohumol
inhibits triglyceride and apolipoprotein B
secretion in HepG2 cells. J Nutr. 2004 Jun;134(6):1340-6. ● Nozawa H. Xanthohumol, the chalcone
from beer hops (Humulus lupulus
L.), is the ligand for farnesoid
X receptor and ameliorate s lipid and glucose metabolism in KK-A(y) mice. Biochem Biophys Res Commun. 2005 Oct 28;336(3):754-61. |
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Thyro-Mend™- is a Trademark of Douglas Laboratories. All
Rights Reserved. |
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♦These statements have not been evaluated by the
Food and Drug Administration. |
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YourMenopauseType.com,
Inc. |
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