|
|
|
||||
|
Estro-Mend™ |
|||||
|
A synergistic combination of isoflavones, phytoestrogens & other
herbs to naturally support optimal estrogen function. |
|||||
|
Favorably affects
estrogen receptors, supporting healthy estrogen function.♦ |
|||||
|
Promotes healthy estrogen
metabolism including 2-hydroxylation which may protect estrogen sensitive
tissues.♦ |
|||||
|
Promotes healthy
function of bone, heart, brain, breasts, vagina and other estrogen sensitive
tissues.♦ |
|||||
|
Relieves many of the
physical and psychological symptoms of menopause, such as hot flushes/night
sweats, irritability, sleep disturbances, vaginal symptoms, mood swings &
memory problems.♦ |
|||||
|
May use without estrogen, or with
bioidentical estrogen to support healthy estrogen function.♦® |
|||||
|
|
|||||
|
|
|||||
|
Please Find a Healthcare Professional in your area to purchase this formulation. |
|||||
|
Three Capsules Contain: |
|
|
|||
|
Isoflavone Complex Proprietary
Blend |
375mg |
||||
|
Pueraria lobata root, Red Clover flowering
tops standardized to 8% isoflavones & soy isoflavone
concentrate NovaSoy® min. 40% isoflavones |
|
||||
|
Black
Cohosh (standardized) |
60mg |
||||
|
standardized to 8% triterpene
glycosides |
|
||||
|
Estro-Mend™
Herbal Proprietary Blend |
1,185mg |
||||
|
Bacopa Monniera (standardized to 20% bacopasides, leaf), Cranberry fruit, Dong
Quai (root), Schisandra (standardized to 0.9% schisandrins,
fruit & seeds), Sage (Salvia officinalis,
leaf) and Hops (aerial parts) |
|||||
|
|
Suggested
Use: |
3 daily with food |
|||
|
|
Also See: |
||||
|
MORE INFORMATION on the Constituents
of Estro-Mend™ |
|
||||
|
Isoflavone Complex: Isoflavones are a class of
phytoestrogens — plant-derived compounds that are similar in structure and/or
function to human estrogens. In plants, isoflavones are usually bound to
glycosides. During digestion, colonic bacteria are thought to metabolize the
inactive isoflavone glycosides into their active
counterparts. Genistein and daidzein, two of the
predominant isoflavones that are beneficial to health, are present in
significant concentrations in soy, Pueraria lobata
(Kudzu) and red clover. These isoflavones promote the 2-hydroxylation
pathway, increasing “good estrogens”. Red Clover provides additional
isoflavones (such as biochanin A, & formononetin), while Pueraria provides additional
isoflavones (such as daidzin, puerarin & 3'-methoxypuerarin) which also contribute
to this isoflavone complex. Isoflavones have both
weak estrogenic and antiestrogenic activity, which
may contribute to their ability to diminish menopausal symptoms and support
maintenance of bone mineral density. Isoflavones may also help protect the
cardiovascular system, support the immune system, inhibit angiogenesis, and
protect against oxidative damage as antioxidants.♦ |
|||||
|
Black Cohosh: The active constituents of Black
Cohosh include the isoflavone formononetin,
as well as triterpenoids, cimicifugoside,
and cinnamic acid derivatives (ferulic
acid, isoferulic acid, and piscidic
and fukiic esters). Black Cohosh appears to
regulate estrogen levels, thereby normalizing hormonal balance and moderating
the symptoms that accompany fluctuating hormone levels. Black cohosh extracts
have exhibited organ specific estrogenic effects and have been characterized
as selective estrogen-receptor modulators. Black Cohosh may suppress
excessive secretion of luteinizing hormone (LH).
Sudden increases in LH secretion, which occur in response to declining
estrogen levels, appear largely responsible for many symptoms associated with
menopause, such as hot flashes, night sweats, insomnia, irritability, heart
palpitations, and headaches. As with other estrogenic compounds, the active
constituents in Black Cohosh extract may have beneficial effects in the
cardiovascular and skeletal systems of postmenopausal women. As such, Black
Cohosh offers a safe and natural method of balancing fluctuating hormone
levels and easing the resulting symptoms that can occur during menopause.♦ |
|||||
|
Bacopa monniera: Bacopa monniera
possesses a potent adaptogenic activity helping the body adapt to both acute and
chronic stress. It has been used for memory enhancement, insomnia and as a
mild sedative. It is also recognized as a potent antioxidant. This
antioxidant capacity of Bacopa may explain, at least in part, the reported antistress, immunomodulatory,
cognition-facilitating, anti-inflammatory and antiaging
effects. Human studies have shown that the actions of Bacopa on cognitive
functioning in normal healthy subjects, including significant improvement in
speed of visual information processing, learning rate and memory
consolidation, have maximal effects evident after 12 weeks. Both acquisition
and retention of memory showed improvement with a significant effect on the
retention of new information and a decreased rate of forgetting of newly
acquired information. Animal
studies also suggest it may have a thyroid-stimulating role.♦ |
|||||
|
Cranberry fruit: Cranberry juice has long been
recognized for its role in supporting urinary tract health. However, when the
whole fruit is used the benefits may extend much further than urinary tract
health. The fruit also contains proanthocyanins and
anthocyanins, two bioflavonoids
known for their antioxidant activity. Anthocyanins
repair and protect DNA integrity and may be beneficial in reducing
age-associated oxidative stress, as well as in improving neuronal and
cognitive brain function. Polyphenolic compounds in
cranberries have been investigated to determine their role in protection
against cardiovascular disease and some cancers. Antioxidant & Antiproliferation activities have also been attributed to
cranberry fruit.♦ |
|||||
|
Dong Quai root: Don Quai, long regarded as a
“female tonic” or “female adaptogen”, has profound benefit in women’s health.
Through its phytoestrogenic action it can decrease symptoms in menopause. It can
increase vaginal lubrication and may increase sexual activity. It may also
increase mucus protection of the digestive system. Normal intestinal mucus is
required for proper bowel function and for immune system health. The immunostimulatory, anti-inflammatory and antiallergenic
properties of Don Quai may support immune system health. Don Quai may promote
reformation of bone and has demonstrated anti-atherosclerotic action. While
able to contribute to health and proper function of so many tissues, it has shown
very weak estrogen receptor binding and does not produce estrogen-like
responses in endometrial thickness.♦ |
|||||
|
Hops: (Humulus lupulus) Hops has been used to reduce hot
flashes in menopausal women and is considered effective in mood disturbances
such as restlessness and anxiety, and sleep disturbances. Some of the
compounds that occur in hops have very strong phytoestrogenic activity such
as 8-prenylnaringenin, which
may have a preventive effect against breast and ovarian cancer. The hop
bitter acids may be responsible for the chemopreventive
action of hops. A catechin trimer
in Humulus lupulus
actually exhibits antioxidant activity greater than alpha-tocopherol
or ascorbic acid. Despite the anti-cancer properties that have been
attributed to hops, its constituents may weakly bind to estrogen receptors
alpha (ER alpha) and beta (ER beta) and exhibit mild estrogenic activity and
up-regulation of progesterone receptors (PR), which may explain why it
effectively relieves menopause symptoms.♦ |
|||||
|
Sage: Sage (Salvia
officinalis) contains phytoestrogen substances that make it very useful for
women. It has been used to treat hot flashes and to decrease perspiration in
both daytime and night-time excessive sweating. Sage has a positive effect on
the nervous system. Human studies have shown it may be even be beneficial in
the management of mild to moderate Alzheimer's disease and can provide
memory-improving properties. Sage binds to the GABA/benzodiazepine receptor
complex in brain tissue and has demonstrated calming actions, even in
agitated patients. Antioxidant glycosides
from sage shown free radical scavenging activity, which may contribute
to its benefits.♦ |
|||||
|
Schisandra: Schisandra may be described as an adaptogen
that supports the normal function of the nervous system, while supporting
cardiovascular health. It also has anti-oxidant and hepatoprotective
properties. Lignans in Schisandra such as schisanhenol may be responsible for its actions. Used for
the treatment of cardiovascular diseases, liver diseases, diseases of the CNS
related to the old age, Schisandra demonstrated a beneficial effect on memory
registration and memory consolidation, and may be useful to prevent age
associated degeneration of the brain.♦ |
|||||
|
References: |
|||||
|
Akhondzadeh S, Noroozian
M, Mohammadi M, Ohadinia
S, Jamshidi AH, Khani M.
Salvia officinalis extract in the treatment of
patients with mild to moderate Alzheimer's disease: a double blind,
randomized and placebo-controlled trial. J Clin Pharm Ther. 2003 Feb;28(1):53-9. Antiproliferative and cytotoxic
effects of prenylated flavonoids
from hops (Humulus lupulus)
in human cancer cell lines.Food Chem
Toxicol. 1999 Apr;37(4):271-85. Bagchi D, Sen
CK, Bagchi M, Atalay M. Anti-angiogenic, antioxidant,
and anti-carcinogenic properties of a novel anthocyanin-rich
berry extract formula. Biochemistry (Mosc). 2004
Jan;69(1):75-80. Beuscher, N. Cimicifuga
racemosa L.- Black Cohosh. Quarterly Review
of Natural Medicine Spring 1996. Blumenthal
M. The Complete German Commission E Monograph: Therapeutic Guide to Herbal
Medicines. |
|||||
|
Chen WJ, Lin JK. Mechanisms of cancer chemoprevention by
hop bitter acids (beer aroma) through induction of apoptosis mediated by Fas and caspase cascades.J Agric Food Chem. 2004 Jan 14;52(1):55-64. Chiu PY, Mak DH, Poon MK, Ko KM. In vivo antioxidant action of a lignan-enriched
extract of Schisandra fruit and an anthraquinone-containing
extract of Polygonum root in comparison with schisandrin B and emodin. Planta Med. 2002 Nov;68(11):951-6. Choy
YM, Leung KN, Cho CS, Wong CK, Pang PK. Immunopharmacological studies of low molecular weight
polysaccharide from Angelica sinensis. Am J Chin
Med. 1994;22(2):137-45. |
|||||
|
Collins, JJ. 2002.
Discover Your Menopause Type. Prima Publishing Daniela T. [Salvia officinalis
l. I. Botanic characteristics, composition, use and cultivation] Cesk Farm. 1993 Jun;42(3):111-6. Slovak. De Leo V, Lanzetta
D, Cazzavacca R, Morgante
G. [Treatment of neurovegetative menopausal
symptoms with a phytotherapeutic agent] Minerva Ginecol.
1998 May;50(5):207-11. Italian. Duke JA. CRC Handbook of Medicinal Herbs. Duker EM, Kopanski L, Jarry H, Wuttke E. Effects of
extracts from Cimicifuga racemosa
on gonadotropin release in menopausal women and ovarectomized rats. Planta Medica 1991;57:420-4. |
|||||
|
Goetz P. Treatment of hot flashes
due to ovarian insufficiency using a hops extract (Humulus
lupus). Rev Phytotherapie Pratique 1990;4:13-15. [Article in French] Hirata JD, Swiersz LM, Zell B, Small R, Ettinger B. Does dong quai have estrogenic
effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril. 1997
Dec;68(6):981-6. Hohmann J, Zupko
I, Redei D, Csanyi M, Falkay G, Mathe I, Janicsak G. Protective effects of the aerial parts of
Salvia officinalis, Melissa Officinalis
and Lavandula angustifolia
and their constituents against enzyme-dependent and enzyme-independent lipid peroxidation. Planta Med. 1999
Aug;65(6):576-8. |
|||||
|
Kar A, Panda S, Bharti
S. Relative efficacy of three medicinal plant
extracts in the alteration of thyroid hormone concentrations in male mice.J Ethnopharmacol. 2002
Jul;81(2):281-5. Kavvadias D, Monschein
V, Sand P, Riederer P, Schreier
P. Constituents of sage (Salvia officinalis) with
in vitro affinity to human brain benzodiazepine receptor. Planta
Med. 2003 Feb;69(2):113-7. |
|||||
|
Kruse SO, Lohning
A, Pauli GF, et al. Fukiic and piscidic
acid esters from the rhizome of Cimicifuga
racemosa and the in vitro estrogenic
activity of fukinolic acid. Planta
Med 1999;65:763-764. Li PC, Poon KT, Ko KM. Schisandra chinensis-dependent myocardial protective action of sheng-mai-san in rats. Am J Chin Med.
1996;24(3-4):255-62. Lieberman
S. A review of the effectiveness of Cimicifuga racemosa (black cohosh) for the symptoms of menopause.
Journal of Womens Health 1998;7:525-9. |
|||||
|
Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou
AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL.
Evaluation of estrogenic activity of plant extracts for the potential
treatment of menopausal symptoms. J Agric Food Chem. 2001 May;49(5):2472-9. Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou
AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL. Evaluation of estrogenic activity of plant extracts for
the potential treatment of menopausal symptoms. J Agric Food Chem. 2001
May;49(5):2472-9. Lu H, Liu GT. Anti-oxidant
activity of dibenzocyclooctene lignans
isolated from Schisandraceae. Planta
Med. 1992 Aug;58(4):311-3. Mahady GB, Fong HHS, Farnsworth NR. Rhizoma
Cimicifuga racemosae.
In: WHO Monographs on Selected Medicinal Plants, Volume II. |
|||||
|
Mills SY. The Dictionary of Modern Herbalism. Miranda CL, Stevens JF, Helmrich
A, Henderson MC, Rodriguez RJ, Yang YH, Deinzer ML,
Barnes DW, Buhler DR. Antiproliferative and cytotoxic effects of prenylated
flavonoids from hops (Humulus
lupulus) in human cancer cell lines. Food Chem Toxicol. 1999
Apr;37(4):271-85. Miranda CL, Stevens JF, Helmrich
A, Henderson MC, Rodriguez RJ, Yang YH, Deinzer ML,
Barnes DW, Buhler DR. Nathan
PJ, Clarke J, Lloyd J, Hutchison CW, |
|||||
|
Nikolic D, Li Y, Chadwick LR, Grubjesic S, Schwab P, Metz P, van Breemen
RB. Metabolism of 8-prenylnaringenin, a potent phytoestrogen
from hops (Humulus lupulus),
by human liver microsomes. Drug Metab
Dispos. 2004 Feb;32(2):272-9. Nikolic D, Li Y, Chadwick LR, Grubjesic S, Schwab P, Metz P, van Breemen
RB. Metabolism of 8-prenylnaringenin, a potent phytoestrogen
from hops (Humulus lupulus),
by human liver microsomesDrug Metab
Dispos. 2004 Feb;32(2):272-9. Nishiyama N, Wang YL, Saito H. Beneficial
effects of S-113m, a novel herbal prescription, on learning impairment model
in mice. Biol Pharm Bull.
1995 Nov;18(11):1498-503. |
|||||
|
Opletal L, Krenkova
M, Havlickova P.
[Phytotherapeutic aspects of diseases of the circulatory system. 7.
Schisandra chinensis (Turcz.)
Baill.): its composition and biological activity] Ceska Slov Farm. 2001
Jul;50(4):173-80. Review. Czech. Opletal L, Krenkova
M, Havlickova P.
[Phytotherapeutic aspects of diseases of the circulatory system. 8. Chinese
magnolia (Schisandra chinensis (Turcz.)
Baill.): production of the drugs and their
evaluation, therapeutic and dietary preparations] Ceska
Slov Farm. 2001 Sep;50(5):219-24. Czech. Ozaki Y. Antiinflammatory
effect of tetramethylpyrazine and ferulic acid. Chem Pharm Bull ( Pan
SY, Han YF, Carlier PR, Pang YP, Mak DH, Lam BY, Ko KM. Schisandrin B protects against
tacrine- and bis(7)-tacrine-induced hepatotoxicity
and enhances cognitive function in mice. Planta
Med. 2002 Mar;68(3):217-20. |
|||||
|
Perry EK, Rai D, Bhatia G, Palit
G, Pal R, Singh S, Singh HK. Adaptogenic effect of
Bacopa monniera (Brahmi).Pharmacol Biochem Behav. 2003 Jul;75(4):823-30. Roodenrys S, Booth D, Bulzomi
S, Phipps A, Micallef C, Smoker J. Chronic effects of Brahmi
(Bacopa monnieri) on human memory. Neuropsychopharmacology. 2002 Aug;27(2):279-81. Russo A, Izzo AA, Borrelli F, Renis M, Vanella A. Free radical
scavenging capacity and protective effect of Bacopa monniera
L. on DNA damage. Phytother Res. 2003
Sep;17(8):870-5. |
|||||
|
Rutherford DM, Nielsen MP, |
|||||
|
Shang P, Qian AR, Yang TH, Jia M, Mei QB, Cho CH, Zhao WM, Chen ZN. Experimental study of anti-tumor effects of polysaccharides
from Angelica sinensis. World J Gastroenterol.
2003 Sep;9(9):1963-7. Stevens JF, Miranda CL, Wolthers
KR, Schimerlik M, Deinzer
ML, Buhler DR. Identification and in vitro biological activities of hop proanthocyanidins: inhibition of nNOS
activity and scavenging of reactive nitrogen species. J Agric Food Chem. 2002
Jun 5;50(12):3435-43. Stough C, Lloyd J, Clarke J, |
|||||
|
Sun J, Togel B, Greve B, Raulin C. Current
therapeutic strategies for hyperhidrosis: a review.
European Journal of Dermatology. Volume 12, Number 3, 219-23, Mai - Juin 2002, Revues
Tripathi YB, Chaurasia
S, Tripathi E, Upadhyay
A, Dubey GP. Bacopa monniera Linn. as an antioxidant: mechanism of action.
Indian J Exp Biol. 1996 Jun;34(6):523-6. Vohora D, Pal SN, Pillai
KK. Protection from phenytoin-induced cognitive
deficit by Bacopa monniera, a reputed Indian nootropic plant.J Ethnopharmacol. 2000 Aug;71(3):383-90. Wang BH, Ouyang JP, Liu YM, Wei
L, Yang JW. [Protective effect of Angelica on
ECV(304) from injury induced by hyperlipidemic
serum in vitro] Sheng Li Xue
Bao. 2001 Jun;53(3):240-3. Chinese. Wang M, Kikuzaki H, Zhu N, Sang S, Nakatani N, Ho CT. Isolation and structural elucidation
of two new glycosides from sage (Salvia officinalis
L.). J Agric Food Chem. 2000 Feb;48(2):235-8. |
|||||
|
Wilasrusmee C, Siddiqui
J, Bruch D, Wilasrusmee S, Kittur
S, Kittur DS. In vitro immunomodulatory effects of herbal products. Am Surg. 2002 Oct;68(10):860-4. Winterhoff H, Butterweck V, Jarry H, Wuttke, W. Pharmacologic and clinical studies using Cimicifuga racemosa in
climacteric complaints. Wien Med Wochenschr 2002;152:360-363.
[Article in German] Yan X, Murphy BT, Hammond GB, Vinson JA, Neto
CC. Antioxidant activities and antitumor
screening of extracts from cranberry fruit (Vaccinium
macrocarpon). J Agric Food Chem. 2002 Oct
9;50(21):5844-9. |
|||||
|
Yang Q, Populo SM, Zhang J, Yang
G, Kodama H. Effect of Angelica sinensis
on the proliferation of human bone cells. Clin Chim Acta. 2002
Oct;324(1-2):89-97. Ye YN, So HL, Liu ES, Shin VY, Cho CH. Effect of polysaccharides from Angelica sinensis on gastric ulcer healing. Life Sci. 2003 Jan 10;72(8):925-32. Zhu DP. Dong quai. Am J Chin Med.
1987;15(3-4):117-25. |
|||||
|
|
|||||
|
Estro-Mend™ is a
Trademark of Douglas Laboratories. All Rights Reserved. |
|||||
|
|
|||||
|
♦These statements have not been evaluated by the
Food and Drug Administration. |
|
||||
|
YourMenopauseType.com, Inc. |
|
||||
|
|||||