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Estro-Mend™ |
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A synergistic combination of isoflavones, phytoestrogens & other
herbs to naturally support optimal estrogen function. |
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Favorably
affects estrogen receptors, supporting healthy estrogen function.♦ |
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Promotes
healthy estrogen metabolism including 2-hydroxylation which may protect
estrogen sensitive tissues.♦ |
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Promotes
healthy function of bone, heart, brain, breasts, vagina and other estrogen
sensitive tissues.♦ |
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Relieves
many of the physical and psychological symptoms of menopause, such as hot
flushes/night sweats, irritability, sleep disturbances, vaginal symptoms,
mood swings & memory problems.♦ |
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May use without estrogen,
or with bioidentical estrogen to support healthy estrogen function.♦® |
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Please Find a Healthcare Professional in your area to purchase this formulation. |
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Three
Capsules Contain: |
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Isoflavone Complex Proprietary Blend |
375mg |
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Pueraria lobata root, Red Clover
flowering tops standardized to 8% isoflavones & soy isoflavone
concentrate NovaSoy® min. 40% isoflavones |
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Black Cohosh (standardized) |
60mg |
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standardized
to 8% triterpene glycosides |
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Estro-Mend™ Herbal Proprietary Blend |
1,185mg |
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Bacopa Monniera (standardized
to 20% bacopasides, leaf), Cranberry fruit, Dong Quai (root),
Schisandra (standardized to 0.9% schisandrins, fruit & seeds), Sage (Salvia
officinalis, leaf) and Hops (aerial parts) |
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Suggested Use: |
3 daily with food |
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Also
See: |
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MORE INFORMATION on
the Constituents of Estro-Mend™ |
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Isoflavone
Complex:
Isoflavones are a class of phytoestrogens — plant-derived compounds that are
similar in structure and/or function to human estrogens. In plants,
isoflavones are usually bound to glycosides. During digestion, colonic
bacteria are thought to metabolize the inactive isoflavone glycosides into
their active counterparts. Genistein and daidzein, two of the predominant
isoflavones that are beneficial to health, are present in significant
concentrations in soy, Pueraria
lobata (Kudzu) and red clover. These isoflavones promote the
2-hydroxylation pathway, increasing “good estrogens”. Red Clover provides
additional isoflavones (such as biochanin A, & formononetin), while Pueraria provides additional
isoflavones (such as daidzin, puerarin & 3'-methoxypuerarin) which
also contribute to this isoflavone complex. Isoflavones have both weak
estrogenic and antiestrogenic activity, which may contribute to their ability
to diminish menopausal symptoms and support maintenance of bone mineral
density. Isoflavones may also help protect the cardiovascular system, support
the immune system, inhibit angiogenesis, and protect against oxidative damage
as antioxidants.♦ |
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Black
Cohosh:
The active constituents of Black Cohosh include the isoflavone formononetin, as
well as triterpenoids, cimicifugoside, and cinnamic acid derivatives (ferulic
acid, isoferulic acid, and piscidic and fukiic esters). Black Cohosh appears
to regulate estrogen levels, thereby normalizing hormonal balance and
moderating the symptoms that accompany fluctuating hormone levels. Black
cohosh extracts have exhibited organ specific estrogenic effects and have
been characterized as selective estrogen-receptor modulators. Black Cohosh
may suppress excessive secretion of luteinizing hormone (LH). Sudden
increases in LH secretion, which occur in response to declining estrogen
levels, appear largely responsible for many symptoms associated with
menopause, such as hot flashes, night sweats, insomnia, irritability, heart
palpitations, and headaches. As with other estrogenic compounds, the active
constituents in Black Cohosh extract may have beneficial effects in the
cardiovascular and skeletal systems of postmenopausal women. As such, Black
Cohosh offers a safe and natural method of balancing fluctuating hormone
levels and easing the resulting symptoms that can occur during menopause.♦ |
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Bacopa
monniera: Bacopa monniera possesses a potent adaptogenic activity helping
the body adapt to both acute and chronic stress. It has been used for memory
enhancement, insomnia and as a mild sedative. It is also recognized as a
potent antioxidant. This antioxidant capacity of Bacopa may explain, at least
in part, the reported antistress, immunomodulatory, cognition-facilitating,
anti-inflammatory and antiaging effects. Human studies have shown that the
actions of Bacopa on cognitive functioning in normal healthy subjects,
including significant improvement in speed of visual information processing,
learning rate and memory consolidation, have maximal effects evident after 12
weeks. Both acquisition and retention of memory showed improvement with a
significant effect on the retention of new information and a decreased rate
of forgetting of newly acquired information. Animal studies also suggest it may
have a thyroid-stimulating role.♦ |
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Cranberry fruit: Cranberry juice has
long been recognized for its role in supporting urinary tract health.
However, when the whole fruit is used the benefits may extend much further
than urinary tract health. The fruit also contains proanthocyanins and
anthocyanins, two bioflavonoids known for their antioxidant activity.
Anthocyanins repair and protect DNA integrity and may be beneficial in
reducing age-associated oxidative stress, as well as in improving neuronal
and cognitive brain function. Polyphenolic compounds in cranberries have been
investigated to determine their role in protection against cardiovascular
disease and some cancers. Antioxidant & Antiproliferation activities have
also been attributed to cranberry fruit.♦ |
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Dong Quai root: Don Quai, long
regarded as a “female tonic” or “female adaptogen”, has profound benefit in
women’s health. Through its phytoestrogenic action it can decrease symptoms
in menopause. It can increase vaginal lubrication and may increase sexual
activity. It may also increase mucus protection of the digestive system.
Normal intestinal mucus is required for proper bowel function and for immune
system health. The immunostimulatory, anti-inflammatory and antiallergenic
properties of Don Quai may support immune system health. Don Quai may promote
reformation of bone and has demonstrated anti-atherosclerotic action. While
able to contribute to health and proper function of so many tissues, it has
shown very weak estrogen receptor binding and does not produce estrogen-like
responses in endometrial thickness.♦ |
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Hops: (Humulus lupulus) Hops has been used
to reduce hot flashes in menopausal women and is considered effective in mood
disturbances such as restlessness and anxiety, and sleep disturbances. Some
of the compounds that occur in hops have very strong phytoestrogenic activity
such as 8-prenylnaringenin,
which may have a preventive effect against breast and ovarian cancer. The hop
bitter acids may be responsible for the chemopreventive action of hops. A
catechin trimer in Humulus lupulus actually exhibits antioxidant activity
greater than alpha-tocopherol or ascorbic acid. Despite the anti-cancer
properties that have been attributed to hops, its constituents may weakly
bind to estrogen receptors alpha (ER alpha) and beta (ER beta) and exhibit
mild estrogenic activity and up-regulation of progesterone receptors (PR),
which may explain why it effectively relieves menopause symptoms.♦ |
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Sage: Sage (Salvia officinalis) contains
phytoestrogen substances that make it very useful for women. It has been used
to treat hot flashes and to decrease perspiration in both daytime and night-time
excessive sweating. Sage has a positive effect on the nervous system. Human
studies have shown it may be even be beneficial in the management of mild to
moderate Alzheimer's disease and can provide memory-improving properties.
Sage binds to the GABA/benzodiazepine receptor complex in brain tissue and
has demonstrated calming actions, even in agitated patients. Antioxidant glycosides from sage shown free
radical scavenging activity, which may contribute to its benefits.♦ |
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Schisandra:
Schisandra
may be described as an adaptogen that supports the normal function of the
nervous system, while supporting cardiovascular health. It also has
anti-oxidant and hepatoprotective properties. Lignans in Schisandra such as
schisanhenol may be responsible for its actions. Used for the treatment of
cardiovascular diseases, liver diseases, diseases of the CNS related to the
old age, Schisandra demonstrated a beneficial effect on memory registration
and memory consolidation, and may be useful to prevent age associated
degeneration of the brain.♦ |
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References: |
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Akhondzadeh S, Noroozian M,
Mohammadi M, Ohadinia S, Jamshidi AH, Khani M. Salvia officinalis extract in
the treatment of patients with mild to moderate Alzheimer's disease: a double
blind, randomized and placebo-controlled trial. J Clin Pharm Ther. 2003
Feb;28(1):53-9. Antiproliferative and cytotoxic effects of
prenylated flavonoids from hops (Humulus lupulus) in human cancer cell
lines.Food Chem Toxicol. 1999 Apr;37(4):271-85. Bagchi D, Sen CK, Bagchi M, Atalay M. Anti-angiogenic, antioxidant, and anti-carcinogenic
properties of a novel anthocyanin-rich berry extract formula. Biochemistry
(Mosc). 2004 Jan;69(1):75-80. Beuscher, N. Cimicifuga
racemosa L.- Black Cohosh. Quarterly Review of Natural Medicine Spring
1996. Blumenthal
M. The Complete German Commission E Monograph: Therapeutic Guide to Herbal
Medicines. |
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Chen WJ, Lin JK. Mechanisms of cancer
chemoprevention by hop bitter acids (beer aroma) through induction of
apoptosis mediated by Fas and caspase cascades.J Agric Food Chem. 2004 Jan
14;52(1):55-64. Chiu PY, Mak DH, Poon MK, Ko KM. In vivo antioxidant action of a lignan-enriched extract
of Schisandra fruit and an anthraquinone-containing extract of Polygonum root
in comparison with schisandrin B and emodin. Planta Med. 2002
Nov;68(11):951-6. Choy
YM, Leung KN, Cho CS, Wong CK, Pang PK.
Immunopharmacological studies of low molecular weight polysaccharide from
Angelica sinensis. Am J Chin Med. 1994;22(2):137-45. |
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Collins,
JJ. 2002. Discover Your Menopause Type. Prima Publishing Daniela T. [Salvia officinalis l.
I. Botanic characteristics, composition, use and cultivation] Cesk Farm. 1993
Jun;42(3):111-6. Slovak. De Leo V, Lanzetta D,
Cazzavacca R, Morgante G. [Treatment of neurovegetative menopausal symptoms
with a phytotherapeutic agent] Minerva Ginecol. 1998 May;50(5):207-11.
Italian. Duke JA. CRC Handbook of
Medicinal Herbs. Duker
EM, Kopanski L, Jarry H, Wuttke E. Effects of extracts from Cimicifuga
racemosa on gonadotropin release in menopausal women and ovarectomized rats. Planta
Medica 1991;57:420-4. |
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Goetz P. Treatment
of hot flashes due to ovarian insufficiency using a hops extract (Humulus
lupus). Rev Phytotherapie Pratique 1990;4:13-15. [Article in
French] Hirata JD, Swiersz LM, Zell B, Small R,
Ettinger B. Does dong quai have estrogenic effects
in postmenopausal women? A double-blind, placebo-controlled trial. Fertil
Steril. 1997 Dec;68(6):981-6. Hohmann J, Zupko I, Redei D, Csanyi M, Falkay G, Mathe I,
Janicsak G. Protective effects of the aerial parts of Salvia officinalis,
Melissa Officinalis and Lavandula angustifolia and their constituents against
enzyme-dependent and enzyme-independent lipid peroxidation. Planta Med. 1999
Aug;65(6):576-8. |
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Kar A, Panda S, Bharti S. Relative efficacy of three medicinal plant extracts in
the alteration of thyroid hormone concentrations in male mice.J
Ethnopharmacol. 2002 Jul;81(2):281-5. Kavvadias D, Monschein V, Sand
P, Riederer P, Schreier P. Constituents of sage (Salvia officinalis) with in
vitro affinity to human brain benzodiazepine receptor. Planta Med. 2003
Feb;69(2):113-7. |
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Kruse SO, Lohning A,
Pauli GF, et al. Fukiic and piscidic acid esters from the rhizome of Cimicifuga
racemosa and the in vitro estrogenic activity of fukinolic acid. Planta
Med 1999;65:763-764. Li PC, Poon KT, Ko KM. Schisandra chinensis-dependent myocardial protective action
of sheng-mai-san in rats. Am J Chin Med. 1996;24(3-4):255-62. Lieberman
S. A review of the effectiveness of Cimicifuga racemosa (black cohosh) for
the symptoms of menopause. Journal of Womens Health 1998;7:525-9. |
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Liu J, Burdette JE, Xu H, Gu C, van Breemen
RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR,
Bolton JL. Evaluation of estrogenic activity of plant extracts for the
potential treatment of menopausal symptoms. J Agric Food Chem. 2001
May;49(5):2472-9. Liu J, Burdette JE, Xu H, Gu C, van Breemen
RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR,
Bolton JL. Evaluation of estrogenic activity of
plant extracts for the potential treatment of menopausal symptoms. J Agric
Food Chem. 2001 May;49(5):2472-9. Lu H, Liu GT. Anti-oxidant
activity of dibenzocyclooctene lignans isolated from Schisandraceae. Planta
Med. 1992 Aug;58(4):311-3. Mahady
GB, Fong HHS, Farnsworth NR. Rhizoma Cimicifuga racemosae. In: WHO
Monographs on Selected Medicinal Plants, Volume II. |
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Mills SY. The Dictionary of
Modern Herbalism. Miranda CL, Stevens JF, Helmrich
A, Henderson MC, Rodriguez RJ, Yang YH, Deinzer ML, Barnes DW, Buhler DR.
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops
(Humulus lupulus) in human cancer cell lines. Food Chem Toxicol. 1999
Apr;37(4):271-85. Miranda CL, Stevens JF, Helmrich A,
Henderson MC, Rodriguez RJ, Yang YH, Deinzer ML, Barnes DW, Buhler DR. Nathan
PJ, Clarke J, Lloyd J, Hutchison CW, |
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Nikolic D, Li Y, Chadwick LR,
Grubjesic S, Schwab P, Metz P, van Breemen RB. Metabolism of
8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by
human liver microsomes. Drug Metab Dispos. 2004 Feb;32(2):272-9. Nikolic D, Li Y, Chadwick LR, Grubjesic S,
Schwab P, Metz P, van Breemen RB. Metabolism of 8-prenylnaringenin, a potent
phytoestrogen from hops (Humulus lupulus), by human liver microsomesDrug
Metab Dispos. 2004 Feb;32(2):272-9. Nishiyama
N, Wang YL, Saito H. Beneficial effects of S-113m,
a novel herbal prescription, on learning impairment model in mice. Biol Pharm
Bull. 1995 Nov;18(11):1498-503. |
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Opletal L, Krenkova M, Havlickova P. [Phytotherapeutic aspects of diseases of the circulatory
system. 7. Schisandra chinensis (Turcz.) Baill.): its composition and
biological activity] Ceska Slov Farm. 2001 Jul;50(4):173-80. Review. Czech. Opletal L, Krenkova M, Havlickova P. [Phytotherapeutic aspects of diseases of the circulatory
system. 8. Chinese magnolia (Schisandra chinensis (Turcz.) Baill.):
production of the drugs and their evaluation, therapeutic and dietary
preparations] Ceska Slov Farm. 2001 Sep;50(5):219-24. Czech. Ozaki Y. Antiinflammatory
effect of tetramethylpyrazine and ferulic acid. Chem Pharm Bull ( Pan
SY, Han YF, Carlier PR, Pang YP, Mak DH, Lam BY, Ko KM. Schisandrin B protects against tacrine- and
bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in
mice. Planta Med. 2002 Mar;68(3):217-20. |
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Perry EK, Rai D, Bhatia G, Palit G, Pal R, Singh S,
Singh HK. Adaptogenic effect of Bacopa monniera
(Brahmi).Pharmacol Biochem Behav. 2003 Jul;75(4):823-30. Roodenrys S, Booth D, Bulzomi S, Phipps A,
Micallef C, Smoker J. Chronic effects of Brahmi (Bacopa
monnieri) on human memory. Neuropsychopharmacology. 2002 Aug;27(2):279-81. Russo A, Izzo AA, Borrelli F, Renis M,
Vanella A. Free radical scavenging capacity and
protective effect of Bacopa monniera L. on DNA damage. Phytother Res. 2003
Sep;17(8):870-5. |
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Rutherford DM, Nielsen MP, |
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Shang P, Qian AR, Yang TH, Jia M, Mei QB,
Cho CH, Zhao WM, Chen ZN. Experimental study of
anti-tumor effects of polysaccharides from Angelica sinensis. World J
Gastroenterol. 2003 Sep;9(9):1963-7. Stevens JF, Miranda CL,
Wolthers KR, Schimerlik M, Deinzer ML, Buhler DR. Identification and in vitro
biological activities of hop proanthocyanidins: inhibition of nNOS activity
and scavenging of reactive nitrogen species. J Agric Food Chem. 2002 Jun
5;50(12):3435-43. Stough C, Lloyd J, Clarke J, |
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Sun J, Togel B,
Greve B, Raulin C. Current therapeutic strategies for hyperhidrosis: a
review. European Journal of Dermatology. Volume 12, Number 3, 219-23, Mai -
Juin 2002, Revues
Tripathi YB, Chaurasia S, Tripathi E,
Upadhyay A, Dubey GP. Bacopa monniera Linn. as an antioxidant:
mechanism of action. Indian J Exp Biol. 1996 Jun;34(6):523-6. Vohora D, Pal SN, Pillai KK. Protection
from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian
nootropic plant.J Ethnopharmacol. 2000 Aug;71(3):383-90. Wang BH, Ouyang JP, Liu YM, Wei L, Yang JW. [Protective effect of Angelica on ECV(304) from injury
induced by hyperlipidemic serum in vitro] Sheng Li Xue Bao. 2001
Jun;53(3):240-3. Chinese. Wang M, Kikuzaki H, Zhu N, Sang S, Nakatani N, Ho CT. Isolation
and structural elucidation of two new glycosides from sage (Salvia
officinalis L.). J Agric Food Chem. 2000 Feb;48(2):235-8. |
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Wilasrusmee C, Siddiqui J, Bruch D,
Wilasrusmee S, Kittur S, Kittur DS. In vitro
immunomodulatory effects of herbal products. Am Surg. 2002 Oct;68(10):860-4. Winterhoff H, Butterweck V, Jarry H, Wuttke,
W. Pharmacologic and clinical studies using Cimicifuga racemosa in
climacteric complaints. Wien Med Wochenschr 2002;152:360-363. [Article
in German] Yan
X, Murphy BT, Hammond GB, Vinson JA, Neto CC.
Antioxidant activities and antitumor screening of extracts from cranberry
fruit (Vaccinium macrocarpon). J Agric Food Chem. 2002 Oct 9;50(21):5844-9. |
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Yang Q, Populo SM, Zhang J, Yang G, Kodama
H. Effect of Angelica sinensis on the proliferation
of human bone cells. Clin Chim Acta. 2002 Oct;324(1-2):89-97. Ye YN, So HL, Liu ES, Shin VY, Cho CH. Effect of polysaccharides from Angelica sinensis on
gastric ulcer healing. Life Sci. 2003 Jan 10;72(8):925-32. Zhu DP. Dong quai. Am J
Chin Med. 1987;15(3-4):117-25. |
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Estro-Mend™
is a Trademark of Douglas Laboratories. All Rights Reserved. |
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♦These statements have not been
evaluated by the Food and Drug Administration. |
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YourMenopauseType.com, Inc. |
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